Returning stalwart Stewart Walters tried hard with the bat, while Corry Verco snared two scalps for the hosts.
Chasing Scarborough’s 9-265, Midland-Guildford lost regular wickets to be bowled out for 135.
Once again, taking wickets with the ball was a challenge for Midland-Guildford’s attack, with three run outs among the nine dismissals.
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The chase also proved too much, with Hayden Cobley dismissed in the first over and youngster Keaton Critchell (10) unable to provide a spark.
Midland-Guildford sits down in 15th place with four rounds to go, playing to avoid the wooden spoon.