Armadale detectives searched the property last Monday as part of Operation Carambola.
Senior constable Sacha Howlett said a tip-off from the public led to the discovery of the sophisticated drug set up, which included hydroponic equipment, fully grown cannabis plants and two grams of cocaine with an estimated street value of $24,000.
A 34-year-old man and a woman (32) have been charged with four offences relating to cultivating and possessing illegal drugs with the intent to sell or supply.
They are due to appear in Armadale Magistrates Court on September 17.
The drug seizure was one of the latest is a series of busts made during Operation Carambola, which wrapped up on Sunday after a three-month police presence in the South East Metropolitan Police district.
Ms Howlett said police relied on information from the public to help them investigate the cultivation, manufacturing and dealing of prohibited drugs.
To report suspicious activity call Crime Stoppers on 1800 333 000.