Ms James will walk 60 kilometres to raise money for the Harry Perkins Institute of Medical Research with the hope that a cure to the deadly disease will one day be found.
This year will be her third time taking part in the walk – an impressive feat considering she is still recovering from major surgery.
“This event means everything to me and is emotional and tough on me each year but I feel so much better knowing I am making a difference to someone, somewhere suffering from this horrible disease,” she said.
“My mum passed away aged 54 which I think is far too young and my aunty passed away the year before mum and it was the toughest time in my life.
“My mum’s twin sister has also fought breast cancer, so the determination behind this is so overwhelming and means so much to me.
“They fought so hard to be here today but unfortunately the disease took over.”
The long walk does not daunt Ms James, who said it was nothing compared to what some women had to go through every day.
People can donate to Ms James’ cause here.
The walk will start on April 2 and end the next day.