Now in its third season, the competition’s best four teams will vie for a new end-of-season Top Four Cup.
The regular season will run between March 19 and August 27, with the Top Four Cup final to be help on September 10.
NPLWA manager Chris Beech said the knockout series had been reintroduced to add a more exciting dimension to the end of the season.
The team that finishes on top of the NPLWA league ladder at the end of the regular season will represent WA in the National Finals Series.
Cockburn’s first game is against Dalmatinac Park on March 19.