The Wheatbelt Highway Safety Review lists the route as having 20 serious crashes in which five people died and 19 others were seriously injured from 2009-2013.
Also on the "high risk" list is a 370km section of the Great Eastern Highway (GEH) and the Great Southern Highway (GSH) between Chidlow and York.
Over the same period, 18 people died on the GEH and five people lost their lives on the GSH.
Safety experts recently toured targeted sections of Wheatbelt roads in an effort to find a solution to reduce death and serious injuries in the region.
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Road Safety Minister Liza Harvey said tour representatives from the Road Safety Commission, Main Roads, WA Police and local government shared their knowledge and sought local opinion.
"Last year, 26 people lost their lives on Wheatbelt roads and we want to ensure we are doing all we can, across all government agencies, to reduce road trauma," Mrs Harvey said.