Spurred on by member Bob Graham, whose father died of cancer earlier this year, the group aims to raise $50,000 for the Cancer Council at the October event in Joondalup.
Mr Graham said his father Ron died of bowel cancer in January, aged 83, giving him more motivation to run this year.
�I went back to the UK to see him when he was alive, held his hand,� he said. �I came back (to Perth) � a week later he passed.�
As part of the fundraising efforts, he has been collecting donations around Joondalup and the running group has held sausage sizzles, with more than $5000 raised so far.
The Joondalup resident said the running group, which he joined six years ago, usually did the most laps during the annual relay.
�I like running � it�s a passion of mine,� he said.
�Each member would probably run 25 laps, which is about 10km.
�Everybody has been touched by cancer.
�It�s not just about my father � it�s about thousands.
�I want to help one person survive cancer.�
Mr Graham said they also hoped to hold an event, called Run for Ron, near Lake Joondalup on October 10 as a warm-up to the Relay for Life from October 17 to 18.
To donate, visit www.relayforlife.org.au and search for the NSRG team.