Paleo diet linked to heart disease biomarker

A KEY biomarker linked to heart disease is more than twice as prevalent in the blood of people on the ‘paleo diet’.

The controversial diet advocates eating meat, vegetables, nuts and limited fruit, therefore excluding grains, legumes, dairy, salt, refined sugar and processed oils.

Heart disease kills one Australian every 12 minutes, and researchers from Edith Cowan University have just completed the world’s first major study examining the impact of the paleo diet on gut bacteria.

Researchers compared 44 people on the diet with 47 following a traditional Australian diet.

They measured the amount of trimethylamine-n-oxide (TMAO) in the participants’ blood.

High levels of TMAO, an organic compound produced in the gut, are associated with an increased risk of cardiovascular disease.

“Those who promote the paleo diet often cite it as beneficial for your gut health, but this research suggests there were adverse differences in those who followed the dietary pattern,” lead researcher Dr Angela Genoni, from ECU’s School of Medical and Health Sciences, said.

She said the reason TMAO was so elevated in people on the paleo diet appeared to be due to the higher intake of red meats, but also because of the lack of whole grain intake.

“The paleo diet excludes all grains and we know that whole grains are a fantastic source of resistant starch, and many other fermentable fibres which are vital to the health of your gut microbiome,” Dr Genoni said.

“Because TMAO is produced in the gut, a lack of whole grains might change the populations of bacteria enough to enable higher production of this compound.

“Additionally, the paleo diet includes greater servings per day of red meat, which provides the precursor compounds to produce TMAO.”