The result meant the Centurions are almost guaranteed a home final in week one, having moved into second spot on the premier league ladder.
Joondalup passed the Tigers’ 164 with one wicket remaining, as their burgeoning rivalry continued.
The visitors had entered the second day’s play needing only 47 runs for victory with five wickets remaining.
But the side collapsed, losing four wickets for only 39 runs to give the hosts a sniff of victory when their ninth wicket fell for 157.
Responsibility fell to remaining batsmen James Boyland and Ty Hopes, who held on to record the one-wicket win.
Early scalps to the Tigers’ Matt Kelly (1-6) and Scott Thornton (3-37) had enabled Claremont-Nedlands to come roaring back into the contest.
Boyland was the hero, coming in at 10 and scoring 11 to guide the side to a first-innings win, in a cliffhanger.
The Centurions face Subiaco Floreat on Saturday.