The event, which has been running since 2007, raises awareness and funds to help cure cancer, the leading cause of death in Australia.
From April 24 to May 2, Tour de Cure participants will ride 1194km on the scenic route between Adelaide and Melbourne, aiming to raise a record $2 million.
This year, Tour de Cure will take more than 180 men and women on the Signature Tour team and donations of $10,000 will be given to nine communities and their selected local cancer projects.
WA riders Matt Fulton, Doug Hanna, Samantha Essfahani, Richard Vause, Gary McGrath, Geoff Bell and Simon Thomas were cycling at Garden City, in Booragoon, last month to kick off the event and let locals know how they could help.
Tour de Cure managing director K�ti Jahromi said that over nine days, the team of riders and their support crew would take the same cancer awareness message to regional communities, who were often forgotten when it came to health education and funding for cancer projects.