Uni boasted the likes of WA opener Will Bosisto and Scorchers duo Ashton Agar and James Muirhead in its line-up at James Oval, but the Swans’ bowlers were on song on day one on Saturday.
Mucciarone was the catalyst with his stunning figures of 6-40 from 18 overs, in a breakthrough performance.
Bevan Bennell chimed in with two crucial wickets, including the prize scalp of Agar.
Tim Armstrong and Jack Baker were also among the wickets.
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In reply, Midland-Guildford is 1-16, with a wicket falling in the five overs it had to face late in the day.
Play resumes on Saturday at 11.40am.