Arson Squad officers will investigate reports of a suspicious fire overnight in Edgecombe Street, Como.
A neighbour observed a fire at the front of the house at about 2am this morning and called emergency services.
The vacant house received damage to the front wall, lounge-room window and rafters.
The house has previously been investigated for a suspicious fire on May 10.
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Police are investigating both incidents today.
Anyone with information that can assist in this investigation can call Crime Stoppers on 1800 333 000.