The gutsy midfielder played his 100th game in the same marquee match three years ago in what was then the Foundation Day Derby.
But he hopes the deja vu ends there because the Royals beat the Falcons by 29 points that Monday in June, 2010.
‘Hopefully we can turn that result around,’ he said.
‘It’s a massive milestone and something I’m really proud of.
‘You think of the names that are among that group, then for little old me to be a part of it, it’s a massive honour and very humbling.’
The 29-year-old has garnered a lot of respect in more than a decade at Arena Joondalup.
With a love of the land and a love of footy, his 11-year career has been a juggle between farming in York and WAFL commitments in Perth.
Guadagnin said the lifestyle kept him disciplined because the onus was on him to maintain a WAFL fitness level while working the land.
He bounced back from a knee reconstruction in 2007 to play some of the best football of his career towards the end of the decade.
‘It was a long road back, being out of the city and away from the club full-time, I couldn’t do all of the rehab, but I got back and all was good,’ he said.
West Perth coach Bill Monaghan touted Guadagnin as one of the side’s most valuable players.
‘Even though he’s not talked about a lot in that regard, he brings wonderful traits to the table,’ he said.
‘He’s no nonsense, he’s strong in the clinches and he’s clean by foot.
‘For him to reach 150 games is a testament to his ability and his resilience.’