The Roos posted a score of 291 the previous week and restricted the visitors to 249 on day two.
Quelch, who lost his main bowling partners to overseas travel and injury, found himself the lone restrainer in a game that carries so much in regards to northern suburbs bragging rights.
He bowled 25.3 overs, including three maidens to finish with 7-84.
Backing him up were Matthew Dzodos (2-69 from 19 overs) and Michael Ardagh (1-26).
In a game of outstanding performances: Wanneroo’s Quelch and Christian Smith with his day-one score of 145, Joondalup’s Josh Inglis was a huge thorn in the Roos side when he scored a magnificent undefeated 91.
Garrick Morgan posted 57 before being caught by Jake Fawcett off the bowling of Quelch.
The remainder of the Joondalup batsmen made starts but Wanneroo prevented them from going on with it. The loss was a costly one for the Centurions, who dropped from top spot to fourth.
Wanneroo remains one place outside the top six but is on equal points with Claremont-Nedlands (fifth) and Fremantle (sixth).
The Roos face Midland-Guildford in a two-day affair at Lilac Hill over the next two Saturdays.
With several players tipped to return, the first grade team will have the opportunity to cement a place in the finals.
Joondalup faces Subiaco-Floreat at home.