Team captain Chris Quelch led from the front with 6/35 while his support attack in Kyle Millar and Matthew Dzodos took two wickets each.
But in reply, Wanneroo lost three wickets when important run scorers, John Rogers (3), Rob Richards (4) and Jake Fawcett (0) went late in the day.
Young star Christian Smith, who last week was included in the Futures League team for WA, is yet to bat.
Smith has accumulated 634 runs at 63.40 so far this season and leads Rob Richards, who has figures of 543 at 36.20.
The lower order will need to concentrate to ensure the team maintains its place in the top six,
Wanneroo is currently sixth on the ladder, equal with fifth placed Fremantle, with both on 80 points, just five points behind Claremont Nedlands.
Second grade demolished the University batting to have the home team back in the shed with just 113 runs on the board.
Jason Parry took 2/23 and Jarrod McPhee 2/26 to lead the bowling for Wanneroo.
In reply, Wanneroo enjoyed Mitch McGee’s innings of 130 not out while Brendan Murray contributed 79 and Adam Henry put together an innings of 37 out of a total 4/260.
Captain Nathan Henry has a decision to make regarding outright victories.
Chris Moses top scored with 68 when the under 17’s made a defendable total of 198 against the Centurions at Iluka Sports Complex.
A win in this match is crucial to Wanneroo as the team is currently ninth on the ladder and 11 points behind Centurions, who are sixth with 119.63.
Braiden Hudson scored 32 for the under 15 team when they managed a total of 123.
In reply Centurions are 0/1 and are in a position where, if they bat through the overs, should win the game.