Williams, in her 22nd SBL season, added six points to her 4690-point career tally, with the Wolves women easily overcoming the Flames 66-48.
The 38-year-old shared milestone honours with Ainsleigh Sanders, who was solid in her 150th game with 11 points.
The men followed it up with a 105-95 victory, celebrating their own milestone with Rhys Smyth (five points) playing his 100th game and scoring his 500th point in the process.
The women’s win, led by Nikita Martin on 15 points, put them in a strong position on top of the table with just four games left for the season.
Importantly, they sit two games clear of the Willetton Tigers who have the chance to get one back on Wanneroo when the Wolves have a bye in week 18.
Wanneroo is chasing its first women’s championship since 1992.
The men faced a must-win against Rockingham to tighten their top-eight spot in a close race for finals contention.
The Wolves were in eighth place heading into the clash, but the 10-point triumph, headed by Rob Huntington (25 points, 10 rebounds) and Trian Iliadis (23 points), pushed them to seventh ” a game clear of Willetton Tigers.
The Wolves return to Joondalup Basketball Stadium this Saturday night.