The sides remain the only two without a loss in 2015, but the Slammers have played seven games to the Wolves' four.
A shootout is on the cards at the Eaton Recreation Centre, with South West averaging 114 points a contest and Joondalup almost 112 as the competition's two biggest scorers.
In a further challenge to the Wolves, they face their first double-header this weekend taking on the third-placed Geraldton Buccaneers at Joondalup Basketball Stadium on Sunday.
The Wolves are coming off a clash where they honoured captain Seb Salinas' 300th game with a 30-point victory over Stirling last Thursday.
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READ NOWSalinas was one of Joondalup's best in the 123-93 victory taking 24 points, seven rebounds and a game-high seven assists.
Trian Iliadis hit 32 points, dropping a formidable seven three pointers from 10 attempts.
The women matched the men's 30-point victory with a 92-62 win over the Senators. Rebecca Mercer was top scorer with 18 points.