The team of 43 riders will join thousands of other participants in the 200km fundraising ride, which benefits the Harry Perkins Institute of Medical Research.
One in two Australian men and one in three Australian women will be diagnosed with cancer before the age of 85.
Funds raised through the ride supports cancer research.
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READ NOWThe Ride to Conquer Cancer is the largest cycling fundraising event in WA and has raised more than $15 million since 2012.
TCD quality, safety and environment manager Brion Sutton said this year the ride would stop in Mandurah on Saturday night and then pass through Rockingham to Victoria Park on Sunday.
“Hopefully Courier readers will see us out and be able to cheer us on,” he said.
Some team members have been training for the event with weekend rides around Kwinana.
Visit www.conquercancer.org.au.