The organisation, which meets at Crawford Lodge in Nedlands, hold various fundraisers to support cancer research.
Friends of Cancer Council president and City Beach resident Pru Cowan said artists had been enthusiastic to donate their work for the auction.
“There are a lot of pieces donated by identities around the city,” Ms Cowan said.
“We have a lot of pieces by Lindsay Calyun, a painting from Felicia Aroney, a painting donated by Ljiljanna Ravlich, a piece by Elizabeth Durack, a piece by local artists Samantha Laden and also Ida Killigrew.
“We also don’t have any administration costs, so every cent we raise goes into cancer research.”
Visitors to the auction are encouraged to give a gold coin on entry and light nibbles and drinks will be provided.