The Nedlands institute will open its doors to the public for the first time since Prime Minister Tony Abbott officially opened the $122 million facility 18 months ago.
Director Peter Leedman said he hoped the behind-the-scenes tours and auditorium presentations would inspire enthusiasm and excitement for science.
"Our open day is an opportunity for people to see where we work, what we do and who we are," Professor Leedman said. Community education manager Pauline Charman said visitors could book hands-on activities at the Lotterywest BioDiscovery Lab and experience what it is really like to work as a medical research scientist.
"We are hoping to inspire the next generation of medical researchers and increase understanding and awareness of our work within the community," Ms Charman said.
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"Our lab researchers will be on call to show exactly what your money goes towards when you donate. It is going to be a truly unique and exciting day."
Ms Charman is a science engagement finalist in the 2015 Premier's Science Awards, to be announced on August 20.